Edward J. Pearce, PhD
Our research is focused in two areas:
1) Immune responses during chronic infections with helminth parasites. These infections induce strong Th2 responses that can be both host-protective but also cause significant immunopathology. We are interested in the interactions between the innate system and CD4+ T cells that lead to Th2 polarization, the roles of the Th2 and related T follicular helper cells during infection, and the mechanisms that regulate the response to prevent excessive immunopathology during chronic infection. We use two parasites for these studies: Schistosoma mansoni, a parasitic flatworm that lives within the vasculature and causes significant liver and intestinal disease, and Heligmosomoides polygyrus, a nematode that lives within the intestinal lumen.
2) Metabolic changes underlying immune cell activation. We are focused on understanding how different metabolic pathways and changes in substrate utilization support or inhibit different activation states. Our particular focus is on dendritic cell activation in response to Toll like receptor agonists, and macrophage activation in response to IL-4/IL-13. Our long-term goal is to manipulate immune cell metabolism in order to enhance immune responses during chronic infection and cancer.
Fairfax KC, Everts B, Smith AM, Pearce EJ. Regulation of the Development of
the Hepatic B Cell Compartment during Schistosoma mansoni Infection. J Immunol.
2013 Sep 13. [Epub ahead of print] PubMed PMID: 24038090.
van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang
CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL. CD8 memory T cells
have a bioenergetic advantage that underlies their rapid recall ability. Proc
Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41. doi: 10.1073/pnas.1221740110. Epub 2013 Aug 12. PubMed PMID: 23940348; PubMed Central PMCID: PMC3761631.
Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang
SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL.
Posttranscriptional control of T cell effector function by aerobic glycolysis.
Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016. PubMed PMID:
Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and
quiescence. Immunity. 2013 Apr 18;38(4):633-43. doi:
10.1016/j.immuni.2013.04.005. Review. PubMed PMID: 23601682; PubMed Central
McCarthy SA, Mufson RA, Pearce EJ, Rathmell JC, Howcroft TK. Metabolic
reprogramming of the immune response in the tumor microenvironment. Cancer Biol Ther. 2013 Apr;14(4):315-8. doi: 10.4161/cbt.23616. Epub 2013 Jan 28. PubMed
PMID: 23358474; PubMed Central PMCID: PMC3667870.
Amiel E, Everts B, Freitas TC, King IL, Curtis JD, Pearce EL, Pearce EJ.
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation
and enhances therapeutic autologous vaccination in mice. J Immunol. 2012 Sep
1;189(5):2151-8. doi: 10.4049/jimmunol.1103741. Epub 2012 Jul 23. PubMed PMID:22826320; PubMed Central PMCID: PMC3424310.
Everts B, Amiel E, van der Windt GJ, Freitas TC, Chott R, Yarasheski KE,
Pearce EL, Pearce EJ. Commitment to glycolysis sustains survival of NO-producing
inflammatory dendritic cells. Blood. 2012 Aug 16;120(7):1422-31. doi:
10.1182/blood-2012-03-419747. Epub 2012 Jul 11. PubMed PMID: 22786879; PubMedCentral PMCID: PMC3423780.
DBBS Graduate Program Affiliation
- Immunology Program
- Molecular Microbiology and Microbial Pathogenesis